The skill to target nearly all of human transcription elements remains an as yet unachieved aim in chemical biology and medication. We developed a modular, synthetic transcriptional repressor platform that recapitulates the DNA-binding properties of native frequent helix-loop-helix (bHLH) domains and could perhaps block the DNA-binding functions of a indubitably famous oncogenic transcription factor target, MYC.
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Fig. 1: Modular arrangement and synthesis of man-made transcriptional repressors.
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That is a summary of: Speltz, T. E. et al. Focusing on MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat. Biotechnol. https://doi.org/10.1038/s41587-022-01504-x (2022).
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Cite this article Synthetic biologics present a path to target bHLH transcription elements.
Nat Biotechnol (2022). https://doi.org/10.1038/s41587-022-01509-6
Published: 03 November 2022